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Shinji Takai Selected Research

acetamide

2/2008Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis.
6/2004A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters.
6/2004A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters.
2/2003A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[,4-dioxo-1-phenyl-7-(2-pyridyloxy)]2-heptyl]acetamide (NK3201), suppressed intimal hyperplasia after balloon injury.
11/2002Development of the chymase inhibitor as an anti-tissue-remodeling drug: myocardial infarction and some other possibilities.

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Shinji Takai Research Topics

Disease

26Fibrosis (Cirrhosis)
10/2020 - 11/2002
15Myocardial Infarction
03/2019 - 06/2002
14Neoplasms (Cancer)
11/2021 - 02/2005
13Inflammation (Inflammations)
10/2020 - 02/2003
12Hypertension (High Blood Pressure)
09/2019 - 10/2002
10Atherosclerosis
03/2010 - 10/2002
10Hyperplasia
09/2007 - 11/2002
9Abdominal Aortic Aneurysm
01/2013 - 06/2004
8Infections
01/2022 - 02/2003
8Cicatrix (Scar)
12/2019 - 05/2002
8Stroke (Strokes)
07/2017 - 07/2005
6Retinal Perforations
02/2021 - 01/2006
6Glaucoma
12/2019 - 05/2002
6Cardiovascular Diseases (Cardiovascular Disease)
04/2016 - 01/2004
6Liver Cirrhosis (Hepatic Cirrhosis)
09/2013 - 10/2006
5Aneurysm (Aneurysms)
02/2010 - 11/2002
4Epiretinal Membrane (Epiretinal Membranes)
02/2021 - 01/2015
4Diabetic Retinopathy (Retinopathy, Diabetic)
01/2021 - 01/2006
4Alcoholic Fatty Liver
10/2020 - 09/2013
4Neointima
05/2020 - 04/2005
4Non-alcoholic Fatty Liver Disease
05/2018 - 05/2010
4Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
08/2013 - 06/2004
4Infarction (Infarctions)
10/2011 - 07/2002
4Cardiomyopathies (Cardiomyopathy)
04/2011 - 02/2002
4Hepatocellular Carcinoma (Hepatoma)
07/2008 - 11/2005
3Ischemia
10/2021 - 01/2004
3Body Weight (Weight, Body)
10/2020 - 03/2004
3Retinal Detachment (Retinal Detachments)
10/2020 - 01/2015
3Pathologic Constriction (Stenosis)
05/2020 - 04/2005
3Blister (Bulla)
12/2019 - 09/2011
3Wounds and Injuries (Trauma)
10/2018 - 05/2002
3Acute Liver Failure (Fulminant Hepatic Failure)
12/2015 - 06/2007
3Vascular Remodeling
08/2014 - 07/2005
3Vascular Diseases (Vascular Disease)
03/2005 - 08/2003
2Pneumonia (Pneumonitis)
06/2022 - 03/2003
2Hypoxia (Hypoxemia)
12/2021 - 07/2009
2Neurodegenerative Diseases (Neurodegenerative Disease)
07/2021 - 11/2009
2Adenocarcinoma
11/2020 - 10/2005
2Albuminuria
10/2020 - 12/2019
2Proteinuria
09/2019 - 09/2010
2Neoplasm Metastasis (Metastasis)
01/2019 - 01/2019
2Cancer Pain
01/2019 - 01/2019

Drug/Important Bio-Agent (IBA)

72Chymases (Chymase)IBA
11/2021 - 02/2002
31Angiotensin IIIBA
10/2020 - 10/2002
14Matrix Metalloproteinase 9 (Gelatinase B)IBA
01/2019 - 10/2004
14Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
01/2013 - 02/2002
13Matrix Metalloproteinases (MMPs)IBA
10/2020 - 01/2006
12Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2013 - 02/2002
9NK3201IBA
07/2009 - 11/2002
8CholesterolIBA
05/2018 - 10/2002
7Tryptases (Tryptase)IBA
01/2021 - 06/2004
6Proteins (Proteins, Gene)FDA Link
12/2020 - 05/2007
6Transforming Growth Factors (Transforming Growth Factor)IBA
10/2020 - 01/2008
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2014 - 11/2004
6AngiotensinsIBA
06/2012 - 02/2002
6Transforming Growth Factor beta (TGF-beta)IBA
11/2009 - 04/2003
6EnzymesIBA
06/2009 - 02/2002
5Biomarkers (Surrogate Marker)IBA
10/2021 - 02/2003
5candesartanIBA
01/2019 - 07/2006
5TY 51469IBA
07/2017 - 08/2010
5Valsartan (Vals)FDA Link
04/2013 - 12/2007
5Angiotensin Receptor AntagonistsIBA
08/2008 - 07/2004
5acetamideIBA
02/2008 - 11/2002
4Serine Proteases (Serine Protease)IBA
01/2021 - 01/2015
4Eplerenone (Inspra)FDA LinkGeneric
09/2019 - 11/2005
4Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
09/2019 - 11/2005
4AldosteroneIBA
06/2012 - 11/2005
4CytokinesIBA
12/2009 - 11/2004
4HSP27 Heat-Shock ProteinsIBA
07/2008 - 11/2005
4Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2008 - 06/2005
3Proliferating Cell Nuclear Antigen (PCNA)IBA
11/2021 - 09/2011
3AntibodiesIBA
02/2021 - 01/2006
3Polytetrafluoroethylene (Teflon)FDA Link
05/2020 - 09/2007
3Mitomycin (Mitomycin-C)FDA LinkGeneric
12/2019 - 10/2009
3Reactive Oxygen Species (Oxygen Radicals)IBA
09/2019 - 10/2005
3Messenger RNA (mRNA)IBA
10/2018 - 04/2003
3Peptide Hydrolases (Proteases)FDA Link
01/2018 - 12/2009
3HydrogelsIBA
05/2017 - 09/2011
3GelatinIBA
05/2017 - 09/2011
3GalactosamineIBA
12/2015 - 06/2007
3LipopolysaccharidesIBA
12/2015 - 11/2012
3Amlodipine (Norvasc)FDA LinkGeneric
04/2013 - 09/2010
3Pancreatic Elastase (Elastase)IBA
01/2013 - 06/2004
3p38 Mitogen-Activated Protein KinasesIBA
11/2009 - 06/2005
3olmesartanIBA
10/2009 - 10/2005
3trandolapril (Mavik)FDA LinkGeneric
05/2007 - 07/2002
2CreatinineIBA
10/2021 - 06/2012
2salicylhydroxamic acid (SHAM)IBA
10/2021 - 10/2018
2PlatinumIBA
01/2020 - 06/2017
2CollagenIBA
12/2019 - 08/2009
2tempolIBA
09/2019 - 04/2007
2SaltsIBA
09/2019 - 01/2018
2Indicators and Reagents (Reagents)IBA
01/2019 - 11/2005

Therapy/Procedure

10Therapeutics
06/2017 - 11/2004
5Filtering Surgery
12/2019 - 05/2002
4Drug Therapy (Chemotherapy)
01/2020 - 02/2005
4Ligation
11/2012 - 05/2004
3Renal Dialysis (Hemodialysis)
05/2020 - 04/2005
2Vitrectomy
02/2021 - 01/2015
2Lasers (Laser)
01/2019 - 10/2002